Stefano Biffo

This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.

CIA provides a reference-free method for cell type annotation in scRNA-seq data, outperforming existing approaches with lower computational cost.

This study identifies cotranslational degradation of mutant sacsin as the cause of ARSACS, explaining the lack of genotype-phenotype correlation and suggesting sacsin levels should be included in diagnostic algorithms.

This study shows that eIF6 upregulation in Drosophila enhances general translation and inhibits ecdysone biosynthesis, affecting development and metabolism.