Author

Samuel A. Safran

Weizmann Institute of ScienceORCID 0000-0002-0798-1492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Amit KumariD· 1 shared Avital Steinberg· 1 shared Dana LorberiD· 1 shared Emanuele LocatelliiD· 1 shared Emmanuel D. LevyiD· 1 shared Eyal ShimoniiD· 1 shared Ido AzuriiD· 1 shared Jonathan P. K. DoyeiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Amit KumarORCID

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2 papers

Recent·Most cited

Chromatin tethering to the nuclear envelope enhances its accessibility to RNAPII and promotes chromatin asymmetric organization

Dana Lorber, Ido Azuri, Amit Kumar, Ron Rotkopf, Samuel A. Safran, Talila Volk

The paper shows that chromatin tethering to the nuclear envelope prevents clustering and enhances RNAPII accessibility, promoting asymmetric chromatin organization in Drosophila muscle nuclei.

bioRxiv · Mar 18, 2026 · PreprintMolecular Biology

Designer protein assemblies with tunable phase diagrams in living cells

Meta Heidenreich, Joseph M. Georgeson, Emanuele Locatelli, Lorenzo Rovigatti, Saroj Kumar Nandi, Avital Steinberg, Yotam Nadav, Eyal Shimoni, Samuel A. Safran, Jonathan P. K. Doye, Emmanuel D. Levy

The paper designs proteins that form tunable assemblies in cells and maps their phase diagrams to understand how interactions influence mesoscale structures.

Nature Chemical Biology · Jul 13, 2020Peer-reviewedSynthetic Biology