Karen Zito

Synaptic Plasticity as a Function of the Temporal Derivative

The paper tests if synaptic plasticity depends on the temporal derivative of neural activity, finding LTP for positive derivatives and LTD for negative ones, with no change in stable conditions.

A synapse-specific refractory period for plasticity at individual dendritic spines

The paper investigates a synapse-specific refractory period for plasticity at dendritic spines, showing it is linked to reduced CaMKII signaling and can be overcome by increasing PSD95 levels.

D-Serine inhibits non-ionotropic NMDA receptor signaling

This study shows that D-serine inhibits non-ionotropic NMDA receptor signaling and plasticity by blocking glutamate-induced conformational changes in the absence of co-agonist.

Activity-dependent stabilization of nascent dendritic spines requires non-enzymatic CaMKIIα function

This study shows that structural, not enzymatic, functions of CaMKII are required for activity-dependent stabilization of new dendritic spines.

Reduced D-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia

The paper shows that reduced D-serine in a schizophrenia mouse model enhances non-ionotropic NMDAR signaling, leading to dendritic spine destabilization.

Altered phosphorylation of the proteasome subunit Rpt6 has minimal impact on synaptic plasticity and learning

This study investigates the impact of Rpt6 phosphorylation on synaptic plasticity and learning using mouse models, finding no significant effects on synaptic function or behavior.

Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines

This study shows non-ionotropic NMDA receptor signaling is required for bidirectional dendritic spine plasticity, supporting structural changes during learning and development.

Molecular Mechanisms of Non-ionotropic NMDA Receptor Signaling

This study identifies molecular mechanisms downstream of non-ionotropic NMDA receptor signaling that drive dendritic spine shrinkage and LTD in hippocampal neurons.