Marlo Möller

The paper analyzes genetic ancestry in South African Coloured groups to reveal persistent Khoe-San ancestry and traces Indian Ocean slave trade signatures.

The paper predicts NAT2 genotypes and phenotypes in African populations using bioinformatic tools and next-generation sequencing data to inform pharmacogenetic treatment strategies for tuberculosis.

The paper characterizes structural variation at the 17q21.31 locus in humans and great apes, identifying new haplotypes and evolutionary dynamics.

This study performs genetic screening of South African Parkinson's disease patients, identifying rare variants and CNVs in known PD genes, highlighting their contribution to disease in an underrepresented population.

The paper evaluates MitoImpute's accuracy in southern African populations and applies it to a TB miWAS, finding limited success in capturing population-specific variants.

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

This study confirms an association between HLA-II region variants and TB susceptibility in admixed South African samples using the LAAA model.

The paper analyzes mitochondrial genomes of Cape buffalo from Addo Elephant National Park, finding a highly divergent mitogenome likely from introgressive hybridization with an extinct species.

The paper uses genetic data to show sex-biased admixture patterns in South Africa due to colonial migration, with European males and Khoe-San females contributing disproportionately to different regions.

The paper infers demographic models of African population history using genomic data, finding a weakly structured stem model explains polymorphism better than archaic introgression.

The paper compares the neutrophil response to Mycobacterium tuberculosis infection between HIV+ individuals with and without TB history, finding distinct gene expression and NETosis patterns in those without TB.

This study identifies ancestry-specific eQTLs in TB-T2D patients using cis-eQTL mapping, revealing variants associated with gene expression that could guide therapeutic targets in African populations.

The paper evaluates the performance of the LAAA model in detecting causal variants in complex admixed southern African populations and recommends using multiple GWAS models.

The paper infers the demographic history of the Nama population and constructs a population-specific recombination map, showing it diverges from existing continental recombination maps.

This study performs a genome-wide association analysis of host genetic variants and MTBC strain infection in two cohorts, identifying 32 SNPs significantly associated with infection risk in the Ghanaian cohort.

The paper reports the first six human whole genome sequences generated and analyzed locally in South Africa, demonstrating high-quality data comparable to international standards.

This study compares RFMix and ADMIXTURE in a complex 5-way admixed population, finding RFMix more accurate for global and local ancestry inference.

This study conducts a sex-stratified genome-wide association study of tuberculosis, identifying sex-specific genetic interactions and candidate genes.

The paper shows that skin pigmentation in African populations, particularly the KhoeSan, is highly heritable and polygenic, with many new genetic loci identified beyond previously known ones.

The paper uses genome-wide data to reveal fine-scale population structure in southern Africa, showing that KhoeSan groups' ancestry is shaped by geography and ecology rather than language or subsistence.