Michael S. Glickman

This study shows that ligand binding inhibits dimerization of the bacterial histidine kinase PdtaS, thereby repressing its activity and multi-ligand sensing.

The paper performs a genome-wide CRISPRi screen in Mycobacterium smegmatis to uncover novel gene functions and drug targets related to the cell envelope.

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

This paper develops a split ALFA tag-nanobody system for protein localization and proximity proteomics in mycobacteria, demonstrating its utility in identifying protein complexes and localization patterns.

This study identifies effluxosomes as dynamic membrane structures in M. tuberculosis that coordinate multi-metal resistance through PacL proteins and P-ATPase pumps.

This study shows that M. tuberculosis uses chalkophores to maintain respiration under copper limitation, which is critical for its virulence in mice.

This study shows that bladder BCG immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity in mice and humans.