Gerard C. Tromp

Cell phenotypes in the biomedical literature: a systematic analysis and text mining corpus

The paper creates a manually annotated corpus of cell phenotype mentions and shows its use in improving named entity recognition and entity linking models.

Epigenome-wide association study of posttraumatic stress disorder in a South African population

This study conducts an epigenome-wide association study of PTSD in a South African population, identifying epigenetic changes and accelerated DNA methylation age associated with PTSD severity and comorbid metabolic syndrome.

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

GWAS in the Southern African context

The paper evaluates the performance of the LAAA model in detecting causal variants in complex admixed southern African populations and recommends using multiple GWAS models.

The Recombination Landscape of the Khoe-San - the Upper Limits of Recombination Divergence in Humans

The paper infers the demographic history of the Nama population and constructs a population-specific recombination map, showing it diverges from existing continental recombination maps.

A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort

This study performs a genome-wide association analysis of host genetic variants and MTBC strain infection in two cohorts, identifying 32 SNPs significantly associated with infection risk in the Ghanaian cohort.

Multi-ancestry Genome- and Phenome-wide Association Studies of Diverticular Disease in Electronic Health Records with Natural Language Processing enriched phenotype algorithm

This study uses NLP to identify diverticular disease from EHRs and performs GWAS and PheWAS across multiple ancestries to find genetic risk variants and clinical associations.

A sex-stratified genome-wide association study of tuberculosis using a multi-ethnic genotyping array

This study conducts a sex-stratified genome-wide association study of tuberculosis, identifying sex-specific genetic interactions and candidate genes.