Brenna M. Henn

The paper analyzes genetic ancestry in South African Coloured groups to reveal persistent Khoe-San ancestry and traces Indian Ocean slave trade signatures.

The paper characterizes structural variation at the 17q21.31 locus in humans and great apes, identifying new haplotypes and evolutionary dynamics.

This paper introduces a rapid algorithm for pedigree inference in endogamous populations, accurately distinguishing relationships and handling reticulations.

The paper tests HLA dissimilarity in Himba pastoralists and finds no evidence of disassortative mating or fitness benefits from HLA differences in either arranged or chosen partnerships.

This paper improves GWAS performance in underrepresented groups by reassigning ambiguous ethnicity codes, using ancestry-matched imputation panels, and incorporating environmental covariates.

The paper develops an epigenetic age predictor that accounts for DNA sequence variation in African populations, finding that genetic variants can influence epigenetic age and longevity.

The paper identifies novel transcripts, eQTLs, and caQTLs in African populations and fine-maps GWAS signals for complex diseases.

The paper examines the fitness consequences of increased homozygosity in the Himba population, finding a significant association between higher FROH and reduced fertility.

The paper uses genetic data to show sex-biased admixture patterns in South Africa due to colonial migration, with European males and Khoe-San females contributing disproportionately to different regions.

The paper infers demographic models of African population history using genomic data, finding a weakly structured stem model explains polymorphism better than archaic introgression.

This paper quantifies how differences in allelic effect sizes across ancestry backgrounds impact GWAS power in admixed populations and finds modeling these differences does not significantly improve results.

The paper analyzes genomic data from the Chabu, a hunter-gatherer group in Ethiopia, revealing a population bottleneck and diverse demographic responses to agropastoralism in East Africa.

The paper infers the demographic history of the Nama population and constructs a population-specific recombination map, showing it diverges from existing continental recombination maps.

This study shows that using admixed populations in GWAS increases statistical power and improves cross-population polygenic score accuracy compared to single-ancestry populations.

This study identifies DNA methylation markers in human bone to predict age accurately, outperforming morphometric markers.

This study conducts a sex-stratified genome-wide association study of tuberculosis, identifying sex-specific genetic interactions and candidate genes.

The paper conducts a GWAS in non-European populations, identifies new genetic loci, and highlights the importance of diverse cohorts for understanding complex traits.

The paper shows that skin pigmentation in African populations, particularly the KhoeSan, is highly heritable and polygenic, with many new genetic loci identified beyond previously known ones.

The paper quantifies false negative rates in NGS data and introduces a tool to assess them, showing significant FN rates even in high-coverage datasets.

The paper uses genome-wide data to reveal fine-scale population structure in southern Africa, showing that KhoeSan groups' ancestry is shaped by geography and ecology rather than language or subsistence.

The paper examines how distance from Sub-Saharan Africa correlates with mutational load in diverse human populations, finding that populations further from Africa have higher mutation loads due to recessive mutations.