The paper analyzes mitochondrial genomes of Cape buffalo from Addo Elephant National Park, finding a highly divergent mitogenome likely from introgressive hybridization with an extinct species.

Ecology and Evolution · Jan 1, 2025Peer-reviewedGenetics

Slave Trade and Colonial Expansion Resulted in Strong Sex-Biased Admixture in South Africa

Haiko Schurz, Austin W. Reynolds, Gillian L. Meeks, Simon Gravel, Justin W. Myrick, Fernando Luis Mendez, Cedric J. Werely, Paul D. van Helden, Eileen Garner Hoal, G. David Poznik, Min-Ju Kim, Caitlin Uren, Peter A. Underhill, Marlo Möller, Brenna M. Henn

The paper uses genetic data to show sex-biased admixture patterns in South Africa due to colonial migration, with European males and Khoe-San females contributing disproportionately to different regions.

bioRxiv · Sep 6, 2023 · PreprintGenetics

A weakly structured stem for human origins in Africa

Aaron P. Ragsdale, Timothy D. Weaver, Elizabeth G. Atkinson, Eileen Garner Hoal, Marlo Möller, Brenna M. Henn, Simon Gravel

The paper infers demographic models of African population history using genomic data, finding a weakly structured stem model explains polymorphism better than archaic introgression.

Nature · May 17, 2023Peer-reviewedGenomics

Altered neutrophil extracellular traps in response to Mycobacterium tuberculosis in persons living with HIV with no previous TB and negative TST and IGRA

Elouise E. Kroon, Wilian Correa-Macedo, Roger G. Evans, A Seeger, Louise Engelbrecht, Jurgen Kriel, Ben Loos, Naomi Okugbeni, M Orlova, Pauline Cassart, Craig John Kinnear, GC Tromp, Marlo Möller, RJ Wilkinson, AK Coussens, , Eileen Garner Hoal

The paper compares the neutrophil response to Mycobacterium tuberculosis infection between HIV+ individuals with and without TB history, finding distinct gene expression and NETosis patterns in those without TB.

bioRxiv · Apr 19, 2023 · PreprintGenetics

A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort

Stéphanie Muller, Haiko Schurz, Gerard C. Tromp, Gian D van der Spuy, Eileen Garner Hoal, Paul D. van Helden, Ellis Owusu‐Dabo, Christian G. Meyer, Birgit Muntau, Thorsten Thye, Stefan Niemann, Robin M. Warren, Elizabeth Maria Streicher, Marlo Möller, Craig John Kinnear

This study performs a genome-wide association analysis of host genetic variants and MTBC strain infection in two cohorts, identifying 32 SNPs significantly associated with infection risk in the Ghanaian cohort.

Genomics · Apr 20, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations

Jocelyn Quistrebert, Marianna Orlova, Gaspard Kerner, Le Thi Ton, Nguyễn Trong Luong, Nguyễn Thanh Danh, Quentin B. Vincent, Fabienne Jabot‐Hanin, Yoann Seeleuthner, Jacinta C. Bustamante, Stéphanie Boisson‐Dupuis, Nguyễn Thu Hương, Nguyen Ngoc Ba, Jean‐Laurent Casanova, Christophe Delacourt, , Aurélie Cobat

PLoS Genetics · Mar 4, 2021Peer-reviewedGenetic & Genomic Medicine

Putting RFMix and ADMIXTURE to the test in a complex admixed population

Caitlin Uren, Eileen Garner Hoal, Marlo Möller

This study compares RFMix and ADMIXTURE in a complex 5-way admixed population, finding RFMix more accurate for global and local ancestry inference.

BMC Genetics · Apr 7, 2020Peer-reviewedGenomics

A sex-stratified genome-wide association study of tuberculosis using a multi-ethnic genotyping array

Haiko Schurz, Craig John Kinnear, Christopher R. Gignoux, Genevieve L. Wojcik, Paul D. van Helden, Gerard C. Tromp, Brenna M. Henn, Eileen Garner Hoal, Marlo Möller

This study conducts a sex-stratified genome-wide association study of tuberculosis, identifying sex-specific genetic interactions and candidate genes.

Frontiers in Genetics · Jan 18, 2019Peer-reviewedGenetics

An Unexpectedly Complex Architecture for Skin Pigmentation in Africans

Alicia R. Martin, Meng Hsuan Lin, Julie M. Granka, Justin W. Myrick, Xiaomin Liu, Alexandra Sockell, Elizabeth G. Atkinson, Cedric J. Werely, Marlo Möller, Manjinder S. Sandhu, David M. Kingsley, Eileen Garner Hoal, Xiao Liu, Mark J. Daly, Marcus William Feldman, , Brenna M. Henn

The paper shows that skin pigmentation in African populations, particularly the KhoeSan, is highly heritable and polygenic, with many new genetic loci identified beyond previously known ones.

Cell · Nov 1, 2017Peer-reviewedGenetics

Fine-scale human population structure in southern Africa reflects ecogeographic boundaries

Caitlin Uren, Minju Kim, Alicia R. Martin, Dean Bobo, Christopher R. Gignoux, Paul D. van Helden, Marlo Möller, Eileen Garner Hoal, Brenna M. Henn

The paper uses genome-wide data to reveal fine-scale population structure in southern Africa, showing that KhoeSan groups' ancestry is shaped by geography and ecology rather than language or subsistence.

Genetics · Jul 29, 2016Peer-reviewedGenetics