Cell BiologybioRxivPreprint
APP metabolism is regulated by p97/VCP through an autophagy and endolysosome-dependent mechanism
Adriana Figueroa Garcia, Lisa BRISOIRE, Catherine Baud…·Nicolas Sergeant
This study shows that p97/VCP regulates APP metabolism by controlling its trafficking and autophagy-dependent degradation of APP-CTFs, linking it to Alzheimer's disease pathology.
DOI 10.64898/2026.02.03.703492