Author

Laurie E. Littlepage

University of Notre DameORCID 0000-0002-0839-8274Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Glen L. NieburiD· 2 shared Sarah NanoiD· 2 shared Courtney L. Flatt· 1 shared Isabella WeineriD· 1 shared Laoise M. McNamaraiD· 1 shared N B VolziD· 1 shared Ria GoyaliD· 1 shared Susan E. WaltziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Glen L. NieburORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

An immunocompetent osteoblastic model of mammary cancer bone metastasis established by syngeneic intratibial injection of PyMT mammary carcinoma cells in FVB/N mice

Courtney L. Flatt, Sarah Nano, Ria Goyal, Susan E. Waltz, Glen L. Niebur, Laurie E. Littlepage

This paper develops an immunocompetent mouse model of osteoblastic breast cancer bone metastasis using PyMT-CK(OB) cells and validates its utility for studying immune-dependent bone remodeling mechanisms.

bioRxiv · Jul 9, 2026 · PreprintCancer Biology

Osteoblasts Exert a Pro-Tumorigenic Effect on Breast Cancer Spheroids Through CXCL5/CXCR2 Signaling In 2D And 3D Bone Mimetic Cultures

Sarah Nano, Syeda Masooma Naqvi, Isabella Weiner, N B Volz, Vatsal Kumar, Laurie E. Littlepage, Laoise M. McNamara, Glen L. Niebur

This study shows osteoblasts promote breast cancer growth via CXCL5/CXCR2 signaling in 2D and 3D bone-like cultures, with osteoblasts having a stronger effect in 3D models.

bioRxiv · Nov 26, 2025 · PreprintBioengineering