Laoise M. McNamara

Early intermittent low-dose sclerostin antibody treatment promotes surface bone formation and reduces bone loss, but also decreases osteocyte apoptosis and mechanotransduction in ovariectomized rats: a pilot study

Osteoblasts Exert a Pro-Tumorigenic Effect on Breast Cancer Spheroids Through CXCL5/CXCR2 Signaling In 2D And 3D Bone Mimetic Cultures

This study shows osteoblasts promote breast cancer growth via CXCL5/CXCR2 signaling in 2D and 3D bone-like cultures, with osteoblasts having a stronger effect in 3D models.

Stress-dependent growth of breast cancer models emerges from a cellular volume checkpoint

This study develops a biophysical model integrating osmolarity and biomechanical feedback to explain stress-dependent growth in breast cancer spheroids, revealing a cellular volume checkpoint for mitosis.

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

Estrogen Deficiency alters Vascularization and Mineralization dynamics: insight from a novel 3D Humanized and Vascularized Bone Organoid Model

This study develops a 3D vascularized bone model to investigate how estrogen deficiency affects vascularization and mineralization in osteoporosis.

Mechanobiological cues to bone cells during early metastasis drive later osteolysis: a computational mechanoregulation framework prediction

This study uses computational models to predict bone loss during metastasis by linking early mechanical changes to osteolysis.