The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch
Robbert J. van der Pijl, Jochen Gohlke, Joshua G. Strom, Eva L. Peters, Shengyi Shen, Stefan Conijn, Zaynab Hourani, Stephan Lange, Ju Chen, Paul R. Langlais, Siegfried Labeit, Henk L. M. Granzier, Coen A. C. Ottenheijm
The paper identifies MARPs as key modulators of titin-based mechanotransduction and shows mTORC1 regulates longitudinal muscle hypertrophy in response to stretch.
eLife · Jul 30, 2026Peer-reviewedPhysiology