Author

Katherine Leon

University of ChicagoORCID 0000-0002-0870-5000Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Demet AraçiD· 2 shared Kristína CechováiD· 2 shared Reza VafabakhshiD· 2 shared Sumit J. BandekariD· 2 shared Szymon P. KordoniD· 2 shared Anthony A. KossiakoffiD· 1 shared Ethan E. DintzneriD· 1 shared Gracie SifferiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Demet AraçORCID

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2 papers

Recent·Most cited

The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling

Sumit J. Bandekar, Ethan E. Dintzner, Katherine Leon, Szymon P. Kordon, Tomasz Ślężak, Kristína Cechová, Reza Vafabakhsh, Demet Araç

This study investigates how the CUB domain of ADGRG6 regulates receptor signaling by modulating conformational dynamics of the extracellular region.

Proceedings of the National Academy of Sciences · Nov 26, 2025Peer-reviewedBiochemistry

Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains

Szymon P. Kordon, Kristína Cechová, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, Demet Araç

This study uses cryo-EM and single-molecule FRET to show conformational coupling between the extracellular and transmembrane domains of an aGPCR, revealing how ECR dynamics influence receptor function.

Nature Communications · Dec 3, 2024Peer-reviewedBiochemistry