Author

Demet Araç

University of ChicagoORCID 0000-0002-5444-5799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:Drosophila· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Engin ÖzkaniD· 2 shared Katherine LeoniD· 2 shared Kristína CechováiD· 2 shared Reza VafabakhshiD· 2 shared Sumit J. BandekariD· 2 shared Szymon P. KordoniD· 2 shared Andrew G. DilliniD· 1 shared Anthony A. KossiakoffiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Engin ÖzkanORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeuroscienceCurrent BiologyPeer-reviewedSep 21, 2026

Heterophilic interactions between cell-surface proteins Teneurin-m and Capricious drive dendrite segregation in the Drosophila olfactory circuit

Hui Ji, Jingxian Li, Yizhen Xu…·Liqun Luo

1 citation

Drosophilaexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 6, 2026

The Adhesion GPCR Flamingo-Like 1 (FMIL-1) Directs Synapse Formation in a Nociceptive Circuit

Tyler Kennedy, Damilola Oje, Kylie Howerter…·David M. Miller

The paper identifies FMIL-1 as a gene that directs synapse formation in a C. elegans nociceptive circuit by promoting connectivity between PVD neurons and PVC/AVA interneurons.

DOI 10.64898/2026.09.01.748526

C. elegansexperimental assay

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedNov 26, 2025

The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling

Sumit J. Bandekar, Ethan E. Dintzner, Katherine Leon…·Demet Araç

This study investigates how the CUB domain of ADGRG6 regulates receptor signaling by modulating conformational dynamics of the extracellular region.

5 citations

humanexperimental assay

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedDec 3, 2024

Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains

Szymon P. Kordon, Kristína Cechová, Sumit J. Bandekar…·Demet Araç

This study uses cryo-EM and single-molecule FRET to show conformational coupling between the extracellular and transmembrane domains of an aGPCR, revealing how ECR dynamics influence receptor function.

28 citations

cryo-EMexperimental assay

𝕏 PostBluesky