Gracie Siffer

This study uses cryo-EM and single-molecule FRET to show conformational coupling between the extracellular and transmembrane domains of an aGPCR, revealing how ECR dynamics influence receptor function.

This study shows UBQLN2 stabilizes substrates by recruiting E3 ligases, which promotes phase separation and protects against proteasomal degradation, and this mechanism is disrupted in ALS mutants.