Sumit J. Bandekar

This study investigates how the CUB domain of ADGRG6 regulates receptor signaling by modulating conformational dynamics of the extracellular region.

This study uses cryo-EM and single-molecule FRET to show conformational coupling between the extracellular and transmembrane domains of an aGPCR, revealing how ECR dynamics influence receptor function.

This study determines the structure of the CELSR1 extracellular region and shows how specific domains form a compact module to regulate cellular adhesion.