Author

Yubin Chen

Duke UniversityORCID 0000-0002-3566-5366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Jen‐Tsan ChiiD· 3 shared Ssu-Yu CheniD· 3 shared Chao‐Chieh LiniD· 2 shared Scott FloydiD· 2 shared Yasaman SetayeshpouriD· 2 shared Chao-Chieh Lin· 1 shared Chiara Federico· 1 shared Denise Dunn· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPharmacology & Toxicology

Jen‐Tsan ChiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The KRAS G12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders

Ssu-Yu Chen, You Zou, Jianli Wu, Gibeom Nam, Hyejin Lee, Yubin Chen, Chiara Federico, Yasaman Setayeshpour, Chao‐Chieh Lin, Shao-Chin Wu, J.H. Strickler, Jiyong Hong, Michael C. Fitzgerald, Jen‐Tsan Chi

This study identifies RBM39 as a noncovalent target of the KRAS G12C inhibitor divarasib and reveals an RBM39-INSR signaling axis that influences cytotoxicity.

bioRxiv · Aug 20, 2026 · PreprintPharmacology & Toxicology

Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke

Han Kyu Lee, Chao-Chieh Lin, Denise Dunn, Yubin Chen, Ssu-Yu Chen, Douglas A. Marchuk, Scott Floyd, Jen‐Tsan Chi

This study shows that ATM inhibition with AZD1390 reduces ferroptosis and neuronal death in ischemic stroke models.

bioRxiv · Feb 22, 2025 · PreprintNeuroscience

Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis

Chao‐Chieh Lin, Yi-Tzu Lin, Ssu-Yu Chen, Yasaman Setayeshpour, Yubin Chen, Denise E Dunn, Erik J. Soderblom, Guo-Fang Zhang, Valeriy V Filonenko, Suh Young Jeong, Scott Floyd, Susan J. Hayflick, Ivan T. Gout, Jen‐Tsan Chi

This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.

bioRxiv · May 16, 2024 · PreprintCell Biology