James K. Trevathan

Levodopa induced dyskinesia severity is linked to distinct microstructural alterations in nigrostriatal and brainwide neural circuits

This study investigates how L-DOPA-induced dyskinesia (LID) relates to microstructural changes in brain circuits, finding brainwide alterations beyond the nigrostriatal system.

Systematic Errors in DC Offset Measurement and Mitigation at Neurostimulation Electrodes: Causes, Implications and Solutions

The paper identifies systematic errors in DC offset measurement at neurostimulation electrodes and proposes mitigation strategies to improve electrochemical safety assessments.

Prevalence of sympathetic fibers within the rat cervical vagus, and functional consequence on physiological effects mediated by vagus nerve stimulation (VNS).

This study shows that sympathetic fibers are present in the rat cervical vagus nerve and that stimulating the vagus nerve can activate these fibers, leading to tachycardia rather than bradycardia.

Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's Disease using diffusion imaging and tractography

This study uses diffusion imaging and tractography to analyze structural connectivity changes in a rat model of Parkinson's Disease, identifying lesion-specific and compensatory neural networks.

Epidural Spinal Cord Recordings (ESRs): Sources of Artifact in Stimulation Evoked Compound Action Potentials

This study identifies and characterizes sources of artifact contaminating evoked compound action potentials (ECAPs) in epidural spinal cord recordings, highlighting challenges in distinguishing neural signals from artifacts in a swine model.

In vivo visualization of pig vagus nerve 'vagotopy' using ultrasound

This paper demonstrates the use of intraoperative ultrasound to visualize pig vagus nerve fascicular organization (vagotopy) and improve cuff placement for vagus nerve stimulation.

Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters

The paper introduces automatic methods for quantifying neurotransmitters using fast-scan cyclic voltammetry by improving integration boundary selection.

Sources of Off-Target Effects of Vagus Nerve Stimulation Using the Helical Clinical Lead in Domestic Pigs

The paper identifies specific neuroanatomical pathways causing off-target effects of vagus nerve stimulation in pigs and characterizes dose-response curves for on- and off-target effects.

Functional Vagotopy in the Cervical Vagus Nerve of the Domestic Pig: Implications for the Study of Vagus Nerve Stimulation

The paper characterizes the anatomy of the cervical vagus nerve in domestic pigs, identifying structural features relevant to vagus nerve stimulation and comparing them across species.

Is Vagus Stimulation Brain Washing?

This study shows that cervical vagus nerve stimulation increases cerebrospinal fluid penetration into the brain, suggesting potential clinical implications for CNS disorders.