Author

Emma W Vaimberg

Broad InstituteORCID 0000-0002-0890-0041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Mudra HegdeiD· 2 shared Amy B. GoodaleiD· 1 shared Christine StrandiD· 1 shared Cory M Johannessen· 1 shared David E Root· 1 shared David E. RootiD· 1 shared Federica PiccioniiD· 1 shared John G Doench· 1 shared

Activity by Year

2016-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Mudra HegdeORCID

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2 papers

Recent·Most cited

Up, down, and out: optimized libraries for CRISPRa, CRISPRi, and CRISPR-knockout genetic screens

Kendall R Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W Vaimberg, Amy B. Goodale, David E. Root, Federica Piccioni, John G. Doench

The paper evaluates and introduces optimized CRISPR libraries for knockout, interference, and activation screens, showing improved performance in gene function interrogation.

Nature Communications · Dec 17, 2018Peer-reviewedGenomics

Mapping protein function with CRISPR/Cas9-mediated mutagenesis

Katherine F Donovan, Mudra Hegde, Meagan Sullender, Emma W Vaimberg, Cory M Johannessen, David E Root, John G Doench

The paper uses CRISPR/Cas9 mutagenesis to generate allelic variants of MEK1 and BRAF, identifying gain-of-function alleles in the MAPK signaling pathway.

bioRxiv · Sep 23, 2016Genomics