Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-Taiji
Hugang Feng, Daqi Deng, Rashmi Dahiya, Libin Wang, Jingkun Zeng, Benjy J.Y. Tan, Fiona Byrne, Scott T.C. Shepherd, Jiahao Wang, Sarah C. Johnson, Alison Harrod, Karen A. Lane, Annika Fendler, Anne-Laure Cattin, Zayd Tippu, , Samra Turajlic
The paper introduces CRISPR-Taiji to engineer chromosome-specific aneuploidy and characterizes its transcriptomic effects, linking aneuploidy to ccRCC phenotypes.
bioRxiv · Apr 25, 2025 · PreprintGenomics