Daqi Deng

This study investigates how the order of early mutations affects tumor initiation in colorectal cancer using engineered murine organoids, finding that mutation order influences tumorigenic properties and immune interactions.

This study identifies distinct molecular programs in PBRM1- and BAP1-driven ccRCC, explaining their different evolutionary trajectories and clinical outcomes.

This study compares the genomic evolution of sporadic and hereditary colorectal precancers using single-crypt whole-genome sequencing, revealing distinct mutation patterns and evolutionary trajectories.

The paper introduces CRISPR-Taiji to engineer chromosome-specific aneuploidy and characterizes its transcriptomic effects, linking aneuploidy to ccRCC phenotypes.

CIGAR-seq identifies mRNA modification regulators through CRISPR screening and RNA modification readout, revealing NSUN6 as a novel m5C methyltransferase.