mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy
Yining Zhu, Zhi‐Cheng Yao, S.-H. Li, Jingyao Ma, Christine Y. Wei, Di Yu, Jessica L. Stelzel, Bobby Y.X. Ni, Yang Miao, Kyra Van Batavia, Xiaoya Lu, Jinghan Lin, Yifan Dai, Jiayuan Kong, Ruochen Shen, , Hai‐Quan Mao
The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.
bioRxiv · Jan 27, 2025 · PreprintBioengineering