Author

Jiayuan Kong

Johns Hopkins UniversityORCID 0000-0002-5368-8940Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Christine Y. WeiiD· 2 shared Hai‐Quan MaoiD· 2 shared Jinghan LiniD· 2 shared Jingyao MaiD· 2 shared Kailei D. GoodieriD· 2 shared Leonardo ChengiD· 2 shared Xiang LiuiD· 2 shared Xiaoya LuiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Christine Y. WeiORCID

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2 papers

Recent·Most cited

Crosslinking of Lipid Nanoparticles Enhances the Delivery Efficiency and Efficacy of mRNA Vaccines

Xiang Liu, Yining Zhu, Christine Y. Wei, Jinghan Lin, Di Yu, Jiayuan Kong, Fangchi Shao, Jingyao Ma, T. Xu, Xiaoya Lu, Yunhe Su, Kailei D. Goodier, Leonardo Cheng, Wu Han Toh, Christopher J. Erb, , Hai‐Quan Mao

This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.

Nature Chemical Engineering · Feb 16, 2026Peer-reviewedBioengineering

mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy

Yining Zhu, Zhi‐Cheng Yao, S.-H. Li, Jingyao Ma, Christine Y. Wei, Di Yu, Jessica L. Stelzel, Bobby Y.X. Ni, Yang Miao, Kyra Van Batavia, Xiaoya Lu, Jinghan Lin, Yifan Dai, Jiayuan Kong, Ruochen Shen, , Hai‐Quan Mao

The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.

bioRxiv · Jan 27, 2025 · PreprintBioengineering