Amy J. MacQueen

The paper identifies a distinct mode of meiotic chromosome synapsis that occurs independently of homology and is regulated by ATR/Mec1 and Zip1 phosphorylation.

The paper identifies a direct interaction between Zip1 and Zip3 that is essential for crossover formation and synaptonemal complex assembly during meiosis.

This paper shows that SEN1 has three distinct roles in yeast meiosis: enabling IME1 gene expression, preventing DNA:RNA hybrid accumulation, and facilitating double strand break repair and chromosome synapsis.

The paper uses proximity labeling to investigate functional relationships between meiotic recombination and SC proteins in S. cerevisiae, revealing new insights into molecular interactions and defects in crossover-defective mutants.

This study shows that synaptonemal complex proteins influence mismatch repair during meiosis, leading to increased post-meiotic segregation in mutants lacking these proteins.

This study identifies SYCP2 translocation and frameshift variants as causes of male infertility through genetic analysis and functional modeling in yeast.

This study identifies distinct regions in the Zip1 protein that regulate crossover recombination and synapsis in budding yeast, showing their adjacency enables coordination between these processes.