Histone succinylation directly inhibits Jumonji domain demethylases and stabilizes repressive chromatin states
Sarah Graff, Stephanie Stransky, Isaac Kraz, Kheerthana Duraivelan, Alex J. Poppel, Adam G. Chatoff, Nathaniel W. Snyder, S. Garforth, David Shechter, Juan Pablo Maianti, Simone Sidoli
This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.
bioRxiv · Jun 1, 2026 · PreprintBiochemistry