Kerstin Haase

The paper identifies gene dosage effects on telomere maintenance and disease pathways in neuroblastoma using genomic and transcriptomic data from 115 tumors.

Refphase uses multi-sample reference phasing to infer haplotype-specific copy numbers and reveal intra-tumour heterogeneity in cancer samples.

MEDICC2 infers cancer phylogenies from copy-number data, accounting for whole-genome doubling and parallel evolution, and performs well on simulated and real datasets.

The paper benchmarks 31 subclonal reconstruction algorithms on simulated tumours, finding that algorithm choice significantly impacts performance and no single algorithm excels across all tasks.

The paper quantifies selection patterns in cancer evolution using evolutionary genomics methods across 7,664 human cancers, finding positive selection dominates and many driver mutations occur in unknown genes.

This paper introduces a method for allele-specific copy number segmentation across multiple samples, enabling the identification of shared and private segment boundaries for phylogenetic analysis.

The paper identifies multiple mutational signatures linked to tobacco smoking in cancer, reflecting both direct and indirect effects of tobacco smoke on DNA damage and mutation processes.