Author

Emma Colliver

The Francis Crick InstituteORCID 0000-0002-1497-0740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Charles SwantoniD· 5 shared Chris MooreiD· 2 shared Julian DownwardiD· 2 shared Kerstin HaaseiD· 2 shared Míriam Molina‐ArcasiD· 2 shared Nicholas McGranahaniD· 2 shared Peter Van LooiD· 2 shared Roland F. SchwarziD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBioinformatics

Charles SwantonORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Sophie de Carné Trécesson, Philip East, Claire E. Pillsbury, Mariana Silva dos Santos, Hongui Cha, Emma Colliver, Tegan Gilmore, Sareena Rana, Chris Moore, Scott Lighterness, Deborah R. Caswell, Jesse Boumelha, Mona Tomaschko, Romain Baer, Jim E. Eyles, , Julian Downward

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

bioRxiv · Nov 25, 2025 · PreprintCancer Biology

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

Megan Cole, Panayiotis Anastasiou, Claudia Lee, Xiaofei Yu, Andrea de Castro, Jannes Roelink, Chris Moore, Edurne Mugarza, Martin L. Jones, Karishma Valand, Sareena Rana, Emma Colliver, Mihaela Angelova, Katey S.S. Enfield, Alastair J. Magness, , Febe van Maldegem

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

Science Advances · Nov 1, 2024Peer-reviewedCancer Biology

Refphase: Multi-sample reference phasing reveals haplotype-specific copy number heterogeneity

Thomas B.K. Watkins, Emma Colliver, Matthew R. Huska, Tom L. Kaufmann, Emilia L. Lim, Cody B. Duncan, Kerstin Haase, Peter Van Loo, Charles Swanton, Nicholas McGranahan, Roland F. Schwarz

Refphase uses multi-sample reference phasing to infer haplotype-specific copy numbers and reveal intra-tumour heterogeneity in cancer samples.

PLoS Computational Biology · Oct 23, 2023Peer-reviewedBioinformatics

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petković, Thomas B.K. Watkins, Emma Colliver, Sofya Laskina, Nisha Thapa, Darlan Conterno Minussi, Nicholas E. Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi, Roland F. Schwarz

MEDICC2 infers cancer phylogenies from copy-number data, accounting for whole-genome doubling and parallel evolution, and performs well on simulated and real datasets.

Genome biology · Nov 14, 2022Peer-reviewedBioinformatics

cloneMap: a R package to visualise clonal heterogeneity

Alexander M. Frankell, Emma Colliver, Nicholas McGranahan, Charles Swanton

cloneMap visualizes clonal heterogeneity in genomic data by representing clone size and phylogenetic relationships, applied to cancer datasets.

bioRxiv · Jul 26, 2022 · PreprintBioinformatics