Yong Fan

This study shows that heart/foregut-like structures form from human pluripotent stem cells, developing into vascularized cardiac organoids with multiple cell types.

This study uses human organoids to show that PTEN suppresses retinoic acid signaling to drive mesendoderm specification.

This paper describes a method to generate blastocyst-like structures from human pluripotent stem cells and shows they resemble blastocysts in morphology and transcriptome.

This paper introduces iMiGseq, a method for ultra-sensitive mtDNA sequencing in oocytes, revealing hidden heterogeneity and deleterious variants in human and mouse samples.

This study identifies metabolic defects in ALS motor neurons and shows that nicotinamide and SIRT3 activation can rescue these defects.

This study shows YTHDF2 is essential for mouse spermatogenesis and fertility by regulating transcript transitions during spermatogonial differentiation.