Sarah Johnson

TRACE identifies archaic ancestry using ancestral recombination graphs from contemporary genomes, revealing ghost admixture and challenging existing interpretations of archaic introgression.

The paper shows that reducing rDNA copy number in S. cerevisiae changes its replication timing, delays genome replication, and links rDNA to cell cycle control via Cdc14p sequestration.

The paper creates a proteomic resource profiling 90 drugs in six cell lines, revealing cell-specific responses and enabling integration with transcriptional data to identify therapeutic opportunities.

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.