BiochemistrybioRxivPreprint
Structural mechanism of TRPC3 inhibition by a potent and selective antagonist
Jodie Collingridge, Bethan A. Cole, John Liddle…·Esther B E Becker
This study identifies a potent and selective TRPC3 inhibitor, GSK2820986A, and elucidates its binding mechanism through molecular dynamics and functional assays.