Author
University of LeedsORCID 0000-0002-6214-016XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Emily A. Caseley, Katie J. Simmons, Bethan A. Cole…·Jonathan D. Lippiat
This study identifies eight structurally diverse KCNT1 channel inhibitors through virtual screening and experimental validation, offering potential new treatments for KCNT1-associated epilepsy.
Jodie Collingridge, Bethan A. Cole, John Liddle…·Esther B E Becker
This study identifies a potent and selective TRPC3 inhibitor, GSK2820986A, and elucidates its binding mechanism through molecular dynamics and functional assays.
Michael G. Ricos, Bethan A. Cole, Rashid Hussain…·Jonathan D. Lippiat
This study identifies two existing drugs that reduce KCNT1 channel activity and seizure activity in Drosophila models, suggesting potential new treatments for KCNT1-epilepsy.
Bethan A. Cole, Nadia Pilati, Jonathan D. Lippiat
This study investigates how epilepsy-causing KCNT1 variants increase KNa1.1 channel activity by disrupting activation and selectivity filter gates.