Cell BiologyEMBO ReportsPeer-reviewed
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4
Giang Nguyen, Brendan Townsend, Prajakta Gosavi…·Julia K. Pagan
This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.
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