Dominic C.H. Ng

This study identifies prenylation as a regulator of cardiomyocyte proliferation through multiple targets, suggesting its potential for cardiac regeneration.

This study identifies MAPKBP1 as a centrosomal protein that forms a complex with WDR62 and CEP170, essential for PCM cohesion and mitotic spindle formation.

The paper shows that intracellular pH regulates JNK pathway activity through phase separation of its components, affecting signal strength and cellular responses to stress.

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

This study identifies WDR62's role in regulating purine metabolism via the HSP70/HSP90 chaperone network, linking its dysfunction to microcephaly through metabolic enzyme instability.