Molecular BiologyAging CellPeer-reviewed
Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging
Juan P P Jauregui-Lozano, Spencer E. Escobedo, Alyssa Easton…·Hana Hall
This study shows that R-loop accumulation in aging Drosophila photoreceptor neurons correlates with gene expression loss and visual function decline, and that Top3β and RNase H1 can mitigate these effects.
45 citations