Vikki Marie Weake

Defining cell type-specific diurnal gene expression in the mouse retina

The paper identifies cell-type-specific diurnal gene expression patterns in the mouse retina using single-nucleus RNA sequencing.

Chromatin states coordinate diurnal gene expression in the Drosophila retina

The paper shows that chromatin states, not just circadian transcription factors, coordinate diurnal gene expression in Drosophila photoreceptor neurons by aligning gene phases with promoter, enhancer, or repressive chromatin signatures.

PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast Cancer

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

Broad epigenetic shifts in the aging Drosophila retina contribute to its altered rhythmic transcriptome.

This study shows that aging in Drosophila retina causes broad epigenetic shifts, including decreased histone methylation, which disrupt gene expression rhythms despite a functional circadian clock.

One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors

The paper investigates how active histone methylation marks, specifically H3K4me3 and H3K36me3, change with age in Drosophila photoreceptors and their impact on splicing and visual function.

The Clock:cycle complex is a major transcriptional regulator of Drosophila photoreceptors that protects the eye from retinal degeneration and oxidative stress

This study identifies Clock and cycle as neuroprotective circadian regulators in Drosophila photoreceptors that prevent retinal degeneration and oxidative stress during aging.

Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging

This study shows that R-loop accumulation in aging Drosophila photoreceptor neurons correlates with gene expression loss and visual function decline, and that Top3β and RNase H1 can mitigate these effects.

In vivo tissue-specific chromatin profiling in Drosophila melanogaster using GFP-tagged nuclei

The paper develops a method to profile chromatin states in specific Drosophila cell types using GFP-tagged nuclei and applies it to photoreceptor neurons.