Employing single-stranded DNA donors for the high-throughput production of conditional knockout alleles in mice
Denise Grant Lanza, Angelina Gaspero, Isabel Lorenzo, Lan Liao, Ping Zheng, Ying Wang, Yu Deng, Chonghui Cheng, Chuansheng Zhang, Matthew Neil Rasband, John R. Seavitt, Francisco J. DeMayo, Jianming Xu, Mary E. Dickinson, Arthur L. Beaudet, Jason D. Heaney
This study tests CRISPR/Cas9 with ssODNs and lssODNs for generating conditional knockout alleles in mice, finding higher efficiency with lssODNs.
bioRxiv · Sep 29, 2017 · PreprintGenetics