Chonghui Cheng

Rat somatic genome editing enables ER+ breast cancer modeling

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer s disease

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

LINE-associated cryptic splicing induces dsRNA-mediated interferon response and tumor immunity

This study identifies hnRNPM as a suppressor of cryptic splicing and shows its role in preventing dsRNA-mediated interferon responses and tumor immunity.

Co-regulation of alternative splicing by hnRNPM and ESRP1 during EMT

This study identifies co-regulated alternative splicing events by hnRNPM and ESRP1 during EMT, revealing their antagonistic roles and links to cancer survival.

Employing single-stranded DNA donors for the high-throughput production of conditional knockout alleles in mice

This study tests CRISPR/Cas9 with ssODNs and lssODNs for generating conditional knockout alleles in mice, finding higher efficiency with lssODNs.