Yu Deng

Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer s disease

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

Transforming inert cycloalkanes into alpha-omega-diamines through designed enzymatic cascade catalysis

This paper develops a biocatalytic cascade to convert cycloalkanes into aliphatic diamines using microbial consortia, achieving high productivity of 1,6-hexanediamine.

Development of a growth coupled dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin synthesis in E. coli

The paper develops a dynamic regulation network in E. coli to balance malonyl-CoA for enhanced (2S)-naringenin synthesis, achieving an 8.4-fold production improvement with balanced growth.

Machine learning-based promoter strength prediction derived from a fine-tuned synthetic promoter library in Escherichia coli

The paper constructs a synthetic promoter library in E. coli and uses machine learning to predict promoter strength, finding that an XgBoost model achieves optimal performance.

Fine-tuning biosensor dynamic range based on rational design of cross-ribosome-binding sites in bacteria

This study develops a rational design platform using deep learning to predictably tune biosensor dynamic range by optimizing ribosome-binding sites in bacteria.

Employing single-stranded DNA donors for the high-throughput production of conditional knockout alleles in mice

This study tests CRISPR/Cas9 with ssODNs and lssODNs for generating conditional knockout alleles in mice, finding higher efficiency with lssODNs.