Daniel Humphreys

This study identifies clofarabine as an inhibitor of EPEC pathogenesis by targeting bacterial and host translation, revealing a bacterial mechanism to counteract its effects.

This study shows that typhoid toxin from Salmonella Typhi triggers DNA damage responses, leading to antimicrobial effects like lysozyme secretion that inhibit bacterial virulence.

This study identifies ISG15 as a key host defense mechanism against Salmonella typhoid toxin, showing it promotes cell survival and reduces bacterial burden through a STING-dependent pathway.