Yu Pan

Targeted intervention of senescence induced by a 5' half fragment of tRNASec(NCA) with antisense oligonucleotide extends healthspan and lifespan in mice

This study identifies tRNASec(NCA) damage as an aging hallmark and shows that targeting its 5'-fragment with ASO extends healthspan and lifespan in mice.

The fruitENCODE project sheds light on the genetic and epigenetic basis of convergent evolution of climacteric fruit ripening

The fruitENCODE project identifies three evolutionary origins of regulatory circuits governing climacteric fruit ripening through comparative genomics and epigenetics.