Author

Da Zhang

Fudan UniversityPrimary ORCID profile (0000-0002-2613-1354 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Da ZhangiD1 paper · University of California, San Francisco

Biology Disciplines

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Cancer Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew M. LowyiD· 1 shared Beicheng SuniD· 1 shared Benyi LiiD· 1 shared Bo LiniD· 1 shared Chunlan WangiD· 1 shared Cuncong ZhongiD· 1 shared F Y YangiD· 1 shared Gangqi WangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

Andrew M. LowyORCID

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3 papers

Recent·Most cited

MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer

Wang Liu, Lily He, Cuncong Zhong, Yuzhuo Wang, da zhang, Moben Mirza, Benyi Li

This study identifies MZF1-mediated GAPDH overexpression as a driver of glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer, suggesting metabolic targeting as a therapeutic strategy.

Drug Resistance Updates · Aug 1, 2026Peer-reviewedCancer Biology

Fatty acid scavenging enables cancer escape from KRAS inhibition

Zihang Yuan, Bo Lin, Chunlan Wang, Yingying Miao, Da Zhang, Ziru Meng, Gangqi Wang, Andrew M. Lowy, Michael Karin, F Y Yang, Beicheng Sun, Hua Su

The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.

bioRxiv · Apr 3, 2026 · PreprintCancer Biology

Targeted intervention of senescence induced by a 5' half fragment of tRNASec(NCA) with antisense oligonucleotide extends healthspan and lifespan in mice

Kai‐Yue Cao, Long‐Bo Bai, Da Zhang, Yu-Hang Zhang, Rui‐Ze Gong, Tong‐Meng Yan, Yu Pan, Yating Cheng, Zhi-Hong Jiang

This study identifies tRNASec(NCA) damage as an aging hallmark and shows that targeting its 5'-fragment with ASO extends healthspan and lifespan in mice.

bioRxiv · Mar 24, 2025 · PreprintGenetics