Yating Cheng

Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine

This study identifies mannosyl-queuosine (manQ) as an age-related tRNA modification that declines across species and is reversed by queuine supplementation, improving healthspan and lifespan.

Targeted intervention of senescence induced by a 5' half fragment of tRNASec(NCA) with antisense oligonucleotide extends healthspan and lifespan in mice

This study identifies tRNASec(NCA) damage as an aging hallmark and shows that targeting its 5'-fragment with ASO extends healthspan and lifespan in mice.