Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation
Shaobo Wang, Wanyu Li, Jing Wen, Lingling Wang, Shashi Kant Tiwari, William Bray, Lujing Wu, Na Li, Hui Hui, Alex E. Clark, Qiong Zhang, Lingzhi Zhang, Aaron F. Carlin, Tariq M. Rana
This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.
mBio · Nov 17, 2025Peer-reviewedMicrobiology