Wanyu Li

Orthoflaviviruses use diverse binding modes to engage LDLR family receptors

This study determines cryo-EM structures of orthoflaviviruses bound to LDLR family receptors, revealing distinct binding modes and receptor engagement mechanisms.

A pro-apoptotic selection strategy enables CRISPR screening in mosquitoes and identifies Lachesin as a chikungunya virus entry factor

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

Molecular basis for chikungunya virus recognition of a mosquito-specific receptor

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

The HUSH Complex Dictates EBV-transformed B cell Sensitivity to NK Cell Surveillance Through Repression of NKG2A Ligand γ-Proto-cadherin

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

Molecular basis for shifted receptor recognition by an encephalitic arbovirus

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.