Shashi Kant Tiwari

This study examines the cell-type specific effects of opioid use disorder and HIV on the human brain, identifying changes in gene regulation, metabolism, and immune responses across different brain regions.

This study uses human iPSC-derived microglia and 3D cerebral assembloid models to investigate HIV and methamphetamine-induced CNS damage, revealing increased inflammation and neurotoxicity with reduced TREM2 function.

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.