Natalia Baran

The paper identifies small molecules targeting AML by screening for compounds with predicted functions in apoptosis, glutathione metabolism, and autophagy, validating their efficacy in AML cells and patient-derived samples.

This study shows that inhibiting F1 ATP synthase with EB2023 causes transient mitochondrial stress in AML cells, enabling effective treatment without harming healthy tissues.

This study shows that romaciclib combined with venetoclax overcomes venetoclax resistance in AML through synergistic apoptosis induction and suppression of resistance pathways.

This paper identifies a novel MYC-GSPT1 feedback loop and reports a dual degrader, GT19630, that effectively targets MYC-driven cancers with anti-proliferative and apoptotic effects.

This paper develops a PDFF MRI technique to quantify bone marrow fat fraction in mice, showing significant differences with age and radiation, validated by histology.

This study identifies four transcriptionally distinct venetoclax-resistant clusters in AML, revealing phenotypic, genetic, and drug response differences and their implications for treatment resistance.