Author

Prathamesh T. Nadar‐Ponniah

Johns Hopkins UniversityORCID 0000-0002-1087-9069Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Angelika DoetzlhoferiD· 2 shared Charles MorganiD· 2 shared Waldemar KolanusiD· 2 shared Andrés Soto-VarelaiD· 1 shared Cyril MignotiD· 1 shared Edi Lúcia SartoratoiD· 1 shared Elena Chervinsky· 1 shared Eran Cohen‐BarakiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Angelika DoetzlhoferORCID

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4 papers

Recent·Most cited

A Rare Variant in TRIOBP Linked to Occupational Noise Exposure in Meniere Disease

Pablo Cruz‐Granados, Giselle Bianco Bortoletto, Yuzhong Zhang, Prathamesh T. Nadar‐Ponniah, Kiana Bagheri-Loftabad, Edi Lúcia Sartorato, Inés Sánchez‐Sellero, Andrés Soto-Varela, Jose Antonio Lopez-Escamez

The paper identifies a rare TRIOBP variant associated with Meniere disease in individuals with occupational noise exposure.

Genes & Diseases · Dec 19, 2025Peer-reviewedGenetic & Genomic Medicine

Title: The RNA-binding protein TRIM71 is essential for hearing in humans and mice and regulates the timing of auditory sensory organ development

Xiaojun Li, Lin Li, Charles Morgan, Phan Q. Duy, Lale Evsen, Le T. Hao, Roxane Machavoine, Kahina Belhous, Sylvain Ernest, Françoise Denoyelle, Cyril Mignot, Frédéric Brioude, Marine Parodi, He Huang, Prathamesh T. Nadar‐Ponniah, , Angelika Doetzlhofer

This study identifies TRIM71 as essential for hearing in humans and mice, showing it regulates the timing of auditory sensory organ development and prevents premature hair cell differentiation.

bioRxiv · May 29, 2025 · PreprintNeuroscience

Reactivation of the progenitor gene Trim71 enhances the mitotic and hair cell-forming potential of cochlear supporting cells

Xiaojun Li, Charles Morgan, Prathamesh T. Nadar‐Ponniah, Waldemar Kolanus, Angelika Doetzlhofer

This study shows that reactivating Trim71 enhances the regenerative potential of cochlear supporting cells by promoting de-differentiation and hair cell formation.

bioRxiv · Jan 12, 2023 · PreprintNeuroscience

Homozygote loss-of-function variants in the human COCH gene underlie hearing loss

Nada Danial‐Farran, Elena Chervinsky, Prathamesh T. Nadar‐Ponniah, Eran Cohen‐Barak, Shahar Taiber, Morad Khayat, Karen B. Avraham, Stavit Allon Shalev

This study investigates a homozygous frameshift variant in the COCH gene, showing it causes loss-of-function through reduced cochlin translation, impacting genetic counseling for carriers.

European Journal of Human Genetics · Sep 16, 2020Peer-reviewedGenetics