Waldemar Kolanus

This study shows TRIM71 promotes hair cell regeneration by reprogramming supporting cells and activating Sall4 in cochlear organoids and explants.

This study identifies TRIM71 as essential for hearing in humans and mice, showing it regulates the timing of auditory sensory organ development and prevents premature hair cell differentiation.

This study shows that cytohesin-2 is essential for mouse survival and regulates Golgi volume and function through in vivo and in vitro analyses.

This study shows that Trim71 deficiency during gastrulation disrupts gene expression, leading to defects in erythropoiesis and vascular development, causing embryonic lethality.

This study shows that reactivating Trim71 enhances the regenerative potential of cochlear supporting cells by promoting de-differentiation and hair cell formation.

This study shows TRIM71 is essential for germ cell development in mice and links TRIM71 variants to human male infertility.

This study identifies two independent mechanisms by which TRIM71 inhibits let-7 miRNA maturation and activity, impacting developmental and oncogenic processes.

This study investigates how IL4 signalling and NCOR2 regulate the reprogramming of human monocytes into dendritic cells and macrophages, revealing distinct transcriptional and functional profiles based on cytokine exposure timing.