Angelika Doetzlhofer

This study shows TRIM71 promotes hair cell regeneration by reprogramming supporting cells and activating Sall4 in cochlear organoids and explants.

This study identifies Notch1 and Notch2 as mediators of Jagged1's prosensory functions in the cochlea by showing their role in maintaining prosensory progenitors and regulating cell-cycle exit and innervation.

This study shows that Jagged1/Notch signaling maintains cochlear supporting cell progenitor-like characteristics and metabolic genes, and its inhibition enhances hair cell regeneration.

This study shows that CASZ1 regulates outer hair cell maturation and is essential for hearing by controlling gene expression and F-actin density.

This study identifies TRIM71 as essential for hearing in humans and mice, showing it regulates the timing of auditory sensory organ development and prevents premature hair cell differentiation.

This study shows that reactivating Trim71 enhances the regenerative potential of cochlear supporting cells by promoting de-differentiation and hair cell formation.

This study shows that Jagged1 is essential for forming and maintaining Hensen cells in the mouse cochlea, with its loss leading to cell death or conversion into Claudius cells.

This study shows that LIN28B maintains supporting cell plasticity in the cochlea by activating mTOR signaling, enabling hair cell regeneration in immature mice.

This study shows let-7 miRNAs limit pro-sensory cell self-renewal and regulate HC differentiation by targeting CHD7 in the vertebrate inner ear.

This study identifies Activin A signaling as a regulator of hair cell differentiation and terminal mitosis gradients in the mammalian cochlea.