Shahar Taiber

Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition

The paper identifies a rare subpopulation of cochlear supporting cells that transdifferentiate into hair cells upon Notch inhibition, revealing epigenetic and transcriptional changes associated with this process.

Mechano-signaling feedback underlies precise inner hair cell patterning in the organ of Corti

This study identifies a mechano-signaling feedback mechanism that drives precise inner hair cell patterning in the organ of Corti through coordinated cellular movements and adhesion.

Shear forces drive precise patterning of hair cells in the mammalian inner ear

This study shows that shear forces and local repulsion drive the formation of the checkerboard pattern of hair cells in the mammalian inner ear.

Homozygote loss-of-function variants in the human COCH gene underlie hearing loss

This study investigates a homozygous frameshift variant in the COCH gene, showing it causes loss-of-function through reduced cochlin translation, impacting genetic counseling for carriers.

Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1

The paper identifies genetic causes of inherited hearing loss in the Israeli Jewish population, finding a novel deafness gene ATOH1 and demonstrating the effectiveness of targeted genomic sequencing.

Identification and characterization of key long non-coding RNAs in the mouse cochlea

The paper identifies and characterizes four lncRNAs in the mouse cochlea, showing their expression patterns and potential roles in inner ear function.